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KMID : 0361019980410081041
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 8 p.1041 ~ p.1046
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Expression of Matrix Metalloproteinase-2 in the Cervical Lymph Node Metastasis of the Head and Neck Squamous Cell Carcinoma -A Clinicopathologic Study-
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김승현/Seung Hyun Kim
조재식*/임상철/백준/박창수†/Jae Shik Cho*/Sang Chul Lim/Jun Baik/Chang Soo Park†
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Abstract
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Background and Objectives: Death as a result of cancer is primarily due to regional and/or systemic metastasis. The first essential step of metastasis is active migration of cancer cells from their tissue organ. It is associated with the
degradation of extracellular matrix macromolecule, including the basement membrane component of vessels and interstitial stroma. Matrix metalloproteinase-2, one of many matrix degrading enzymes, has been identified as a basement
membrane-degrading
enzyme and is thought to play an important role in the malignant behavior of cancer. But only a little is known about clinicopathologic features of head and neck squamous cell carcinoma in the relation to the production of MMP-2. This study was
designed
to investigate the relationship between MMP-2 expression in the cancer cell membrane and cervical lymph node metastasis in the head and neck squamous cell carcinoma using immunohistochemistry. Materials and Methods: Tissues were obtained
from 55
patients with head and neck cancer who underwent the surgery of primary tumor resection and radical neck dissection. And paraffin embedded 5 ㎛ thin sections were immunohistochemically stained for MMP-2. Results: 1) Immunoreactivity for
MMP-2 was
detected primarily in the cancer cell nests, whereas it was either not observed or observed infrequently and only faintly in the normal epithelium. 2) Metastasis to a lymph node was more frequently observed with the MMP-2 production in the head
and
neck
cancer than that with no expression of MMP-2.(p<0.01). 3) There was no significant correlation between the expression of MMP-2 and the patient's age, tumor size, primary tumor site, clinical tumor stage(TNM classification), and histologic
grading.
Conclusion: These results suggest that intensity of MMP-2 expression in the cancer nests may be a biochemical parameter to predict a metastatic potential, prognosis, and aggressiveness of the head and neck squamous cell carcinoma.
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KEYWORD
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